Planarian regeneration cells. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over two centuries. find that cell-type specialization in neoblasts is dynamic, with fate establishment and fate switching occurring through cell divisions without necessitating a loss of potency. The powerful regenerative ability of planarians benefits from a proliferative cell population that contains pluripotent stem cells, also called neoblast. Recent findings identify key cellular and molecular principles underlying these feats. We find that knockdown of the mitochondrial fusion gene, opa1, impairs both tissue regeneration and stem cell Jan 30, 2025 · The unparalleled regenerative capacity and incredible tissue plasticity of planarians, both resulting from the presence of abundant adult stem cells referred to as neoblasts, offer a unique opportunity to investigate the cellular and molecular principles underlying regeneration. However, the lack of markers to prospectively identify and isolate these adult PSCs has significantly hampered their characterization. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Raz et al. A single pluripotent adult stem cell type ("neoblast") gives rise to the entire range of cell types and organs in the planarian body plan, including a brain, digestive-, excretory-, s …. Dec 13, 2024 · In this study, we examine mitochondrial dynamics during planarian regeneration. Because blastemas do Planarians are members of the Platyhelminthes (flatworms). Jan 30, 2025 · The unparalleled regenerative capacity and incredible tissue plasticity of planarians, both resulting from the presence of abundant adult stem cells referred to as neoblasts, offer a unique opportunity to investigate the cellular and molecular principles underlying regeneration. Abstract The principles underlying regeneration in planarians have been explored for over 100 years through surgical manipulations and cellular observations. These animals have evolved a remarkable stem cell system. A stem cell population (neoblasts) generates new cells and is comprised of pluripotent stem cells (cNeoblasts) and fate-specified Apr 20, 2021 · Neoblasts are adult stem cells that underlie planarian regeneration. The key features of neoblasts are their capacity for indefinite self-renewal, their totipotency and the ability of their progeny to interpret differentiation and polarity signals and correctly replace lost structures after tissue damage. Regeneration is one of the great mysteries of biology. A stem cell population (neoblasts) generates new cells and is comprised of pluripotent stem cells (cNeoblasts) and fate-specified cells Oct 4, 2018 · Abstract Regeneration is one of the great mysteries of biology. Feb 28, 2011 · Planarians are capable of profound regenerative feats dependent upon a population of self-renewing adult stem cells called neoblasts. Planarian regeneration involves the generation of new tissue at the wound site via cell proliferation (blastema formation), and the remodeling of pre-existing tissues to restore symmetry and proportion (morphallaxis). A single pluripotent adult stem cell type (“neoblast”) gives rise to the entire range of cell types and organs in the planarian body plan, including a brain, digestive-, excretory-, sensory- and reproductive systems. Planarians are flatworms capable of regenerating any missing body region, making it an ideal model to study the in‐depth mechanisms of regeneration. Regeneration in Summary Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain tissue homeostasis and regeneration of lost body parts in planarians. 3q jjr3 yee sam lf04 tyee rx 4mgvh9 1uxmi iwf1ys